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13 C editing of glutamate in human brain using J ‐refocused coherence transfer spectroscopy at 4.1 T
Author(s) -
Pan Jullie W.,
Mason Graeme F.,
Vaughan J. Thomas,
Chu WenJang,
Zhang Yantian,
Hetherington Hoby P.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370308
Subject(s) - coherence (philosophical gambling strategy) , nuclear magnetic resonance , spectroscopy , glutamate receptor , pulse sequence , nuclear magnetic resonance spectroscopy , in vivo magnetic resonance spectroscopy , in vivo , chemistry , physics , biophysics , magnetic resonance imaging , biology , medicine , biochemistry , receptor , quantum mechanics , radiology , microbiology and biotechnology
The method of single quantum 13 C editing is analyzed and implemented with water suppressed J ‐refocused coherence transfer spectroscopy. Analysis of the 13 C inversion pulse demonstrates that it is optimally placed into the second echo of the J ‐refocused sequence. We have used this method to acquire 13 C‐edited spectra of glutamate from phantoms and in vivo. The turnover of 13 C4‐labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.