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Proton‐decoupled 19 F spectroscopy of 5‐FU catabolites in human liver
Author(s) -
MurphyBoesch Joseph,
Li Libo He ChunWei,
PadavicShaller Kristin A.,
Negendank William,
Brown Truman R.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370302
Subject(s) - nuclear magnetic resonance , spectral line , proton , spectroscopy , preamplifier , decoupling (probability) , chemistry , materials science , physics , amplifier , optoelectronics , cmos , quantum mechanics , astronomy , control engineering , engineering
An RF network and a dual‐tuned surface coil are described for obtaining proton‐decoupled, NOE enhanced 19 F spectra from a whole body clinical imager operating at 1.5 Tesla. The network removes 19 F frequency noise from the decoupler transmitter and prevents preamplifier saturation from high‐level decoupling signals. Proton decoupling of 19 F spectra was optimized using a sample of urine containing 5‐fluorouracil (5‐FU) and its catabolite fluoro‐β‐alanine (FBAL). Protondecoupled 19 F spectroscopy in vivo is demonstrated by obtaining both nonlocalized spectra and spectra localized with three‐dimensional chemical shift imaging from the liver of patients undergoing 5‐FU chemotherapy.