Premium
Application of a 3D volume 19 FMR imaging protocol for mapping oxygen tension (pO 2 ) in perfluorocarbons at low field
Author(s) -
Pratt Ronald G.,
Zheng Jie,
Stewart Brent K.,
Shiferaw Yoseph,
McGoron Anthony J.,
Samaratunga Ranasinghage C.,
Thomas Stephen R.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370229
Subject(s) - imaging phantom , chemistry , volume (thermodynamics) , nuclear magnetic resonance , deconvolution , signal (programming language) , oxygen tension , analytical chemistry (journal) , oxygen , nuclear medicine , computer science , physics , algorithm , chromatography , medicine , organic chemistry , quantum mechanics , programming language
A limited flip angle gradient‐echo 3D volume acquisition imaging protocol for mapping partial pressure of oxygen (pO 2 ) in perfluorocarbon compounds (PFCs) at low field (0.14 T) is presented. The pO 2 measurement method is based on the paramagnetic effect of dissolved molecular oxygen (O 2 ) which reduces the PFC 19 F T 1− Specific objectives related to imaging of PFCs through use of the protocol include improved image signal‐to‐noise characteristics and elimination of 19 F chemical shift artifacts. A parametric Wiener deconvolution filtering algorithm is used for suppression of 19 F chemical shift artifacts. Application of the protocol is illustrated in a series of calculated pO 2 maps of a gas equilibrated, multi‐chamber phantom containing perfluorotributylamine (FC‐43). The utility of the protocol is demonstrated in vivo through images of a commercially available perfluorocarbon based blood substitute emulsion containing FC‐43 sequestered in the liver and spleen of a rat.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom