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In vivo phosphorus polarization transfer and decoupling from protons in three‐dimensional localized nuclear magnetic resonance spectroscopy of human brain
Author(s) -
Gonen Oded,
Mohebbi Afsaneh,
Stoyanova Radka,
Brown Truman R.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370228
Subject(s) - homonuclear molecule , nuclear magnetic resonance , excitation , polarization (electrochemistry) , imaging phantom , spectroscopy , flip angle , chemistry , proton , nuclear magnetic resonance spectroscopy , atomic physics , physics , magnetic resonance imaging , optics , nuclear physics , molecule , organic chemistry , quantum mechanics , medicine , radiology
Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) from protons ( 1 H) to a J‐coupled phosphorus ( 31 P) has been incorporated into three‐dimensional (3D) chemical‐shift‐imaging (CSI) sequence on a clinical imager. The technique is demonstrated on a phantom and in in vivo human brain. The polarization‐transfer efficiency (∼1.2) is lower than the theoretical maximum of γ 1 H/γ 31 P≈ 2.4 resulting from 1 H‐ 1 H homonuclear J couplings of similar magnitude competing with the 1 H → 31 P transfer. Nevertheless, compared with direct 31 P Ernst‐angle excitation, signal gains of up to × 1.8 were obtained mainly as a result of T 1 differences between 31 P and the 1 H. Spectral interpretation is simplified by editing out all non‐proton‐coupled 31 P signals. The duration, ∼50 min, and power deposition, ∼1 W · kg −1 , make the application suitable for human studies.