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Simultaneous 3D NMR spectroscopy of proton‐decoupled fluorine and phosphorus in human liver during 5‐fluorouracil chemotherapy
Author(s) -
Gonen Oded,
MurphyBoesch Joseph,
Li ChunWei,
PadavicShaller Kristin,
Negendank William G.,
Brown Truman R.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370203
Subject(s) - nuclear magnetic resonance spectroscopy , fluorouracil , fluorine , chemistry , nuclear magnetic resonance , chemotherapy , fluorine 19 nmr , phosphorus , spectroscopy , phosphorus 31 nmr spectroscopy , proton , radiochemistry , medicine , stereochemistry , organic chemistry , physics , quantum mechanics
Simultaneous acquisition of 1 H‐decoupled 31 P and 19 F 3D CSI is demonstrated in the liver of a patient undergoing 5‐fluorouracil chemotherapy. Both 31 P and 19 F shared the same voxel size (64 or 27 ml), bi‐level 1 H‐decoupling and 0.35 s TR. The measurements were done in a 1.5 Tesla clinical imager with three radio‐frequency (RF) channels and a triple‐tuned surface‐coil. The overall MRI and MRS examination time was under 90 min. Simultaneous acquisition of 31 P and 19 F permits localized study of the influence of hepatic metabolism on the uptake and catabolism of fluoropyrimidine drugs without extra measurement time or higher SAR.