Premium
Cerebrospinal fluid‐suppressed high‐resolution diffusion imaging of human brain
Author(s) -
Falconer James C.,
Narayana Ponnada A
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370117
Subject(s) - fluid attenuated inversion recovery , cerebrospinal fluid , diffusion imaging , white matter , nuclear magnetic resonance , nuclear medicine , diffusion mri , partial volume , chemistry , high resolution , effective diffusion coefficient , human brain , magnetic resonance imaging , pathology , medicine , physics , radiology , psychiatry , geology , remote sensing
A cerebrospinal fluid (CSF)‐suppressed flow‐attenuated inversion recovery (FLAIR) double‐shot diffusion echo‐planar imaging (EPI) sequence was developed and used, along with a non‐CSF‐suppressed version of the sequence, to determine the extent of the contribution of CSF partial‐volume averaging to the apparent diffusion coefficients (ADCs) of normal human brain in vivo. Regional analysis indicates that cortical gray matter and parenchymal tissues bordering the ventricles are most affected by CSF contamination, leading to elevated ADC values. Only slight differences in gray‐ and white‐matter average ADCs were detected after CSF suppression. The human brain average ADCs calculated from high‐resolution CSF‐sup‐pressed diffusion‐weighted images in these studies are similar to those reported in animals. FLAIR diffusion sequences remove CSF as a source of error in ADC determination and ischemic lesion discrimination in diffusion‐weighted images (DWI) and ADC maps.