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Unraveling diffusion constants in biological tissue by combining Carr‐Purcell‐Meiboom‐Gill imaging and pulsed field gradient NMR
Author(s) -
van Dusschoten Dagmar,
Moonen Chrit T. W.,
de Jager P. Adrie,
Van As Henk
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360613
Subject(s) - amplitude , diffusion , nuclear magnetic resonance , pulse sequence , pulse (music) , pulsed field gradient , imaging phantom , monte carlo method , spin echo , physics , chemistry , magnetic resonance imaging , mathematics , optics , medicine , statistics , radiology , detector , thermodynamics
A diffusion‐weighted multi‐spin‐echo pulse sequence is presented, which allows for simultaneous measurement of T 2 , the fractional amplitude, and the diffusion constant of different fractions. Monte Carlo simulations demonstrate an improvement of this sequence with respect to the accuracy of diffusion constant and fractional amplitude for slow exchange. Examples are shown for a simple phantom containing two fractions. In addition, experiments on cat brain in healthy condition and following occlusion of the middle cerebral artery show that the fractional amplitude and the diffusion constant of cerebral spinal fluid and normal brain tissue can be analyzed within each pixel with acceptable accuracy.