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Broadband decoupled, 1 H‐localized 13 C MRS of the human brain at 4 tesla
Author(s) -
Gruetter Rolf,
Adriany Gregor,
Merkle Hellmut,
Andersen Peter M.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360503
Subject(s) - nuclear magnetic resonance , heteronuclear molecule , glutamine , chemistry , human brain , magnetization , anisotropy , magnetization transfer , analytical chemistry (journal) , physics , optics , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , magnetic field , medicine , biochemistry , amino acid , quantum mechanics , chromatography , psychiatry , radiology
Broadband proton decoupling of the entire 13 C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2–3 Hz), natural abundance signals from metabolites such as myo ‐inositol, glutamate, N ‐acetyl‐aspartate, and glutamine from 72 cm 3 volumes in the human brain. To overcome the chemical shift displacement error, three‐dimensional localization on the 1 H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal‐to‐noise ratio of 5:1 for 0.07 m M [ 13 C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.