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Changes in water diffusion due to Wallerian degeneration in peripheral nerve
Author(s) -
Beaulieu Christian,
Does Mark D.,
Snyder Richard E.,
Allen Peter S.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360419
Subject(s) - wallerian degeneration , sciatic nerve , diffusion , anatomy , myelin , nuclear magnetic resonance , transverse plane , peripheral , in vivo , effective diffusion coefficient , materials science , chemistry , medicine , magnetic resonance imaging , physics , biology , central nervous system , thermodynamics , microbiology and biotechnology , radiology
The authors report NMR measurements of the changes in water diffusion brought about by in vivo Wallerian degeneration due to either crush‐ or tie‐injuries in the sciatic nerve of the frog. Using a pulsed‐gradient spin‐echo sequence with a diffusion measurement time of 28 ms, the degree of diffusion coefficient anisotropy {D(longitudinal)/D(transverse)} 4 weeks after injury in both crush‐ and tie‐injured nerves (2.3 ± 0.4 and 1.7 ± 0.1, respectively) is significantly less than in normal frog sciatic nerve (3.9 ± 0.4). The decrease of anisotropy in the degenerated nerves is due to both a decrease in longitudinal diffusion and an increase in transverse diffusion. The changes in diffusion coefficients are compared with the degree of axonal and myelin breakdown observed in light and electron micrographs of the nerves.