Effect of ovariectomy on magnetic resonance T 2 * in rat femur | Zendy

Checkley David | Zendy; Millest Andrew J. | Zendy; Johnstone Donna | Zendy; Waterton John C. | Zendy

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Effect of ovariectomy on magnetic resonance T 2 * in rat femur

Author(s) -

Checkley David,

Millest Andrew J.,

Johnstone Donna,

Waterton John C.

Publication year - 1996

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910360411

Subject(s) - osteopenia , femur , magnetic resonance imaging , ex vivo , in vivo , bone mineral , anatomy , nuclear magnetic resonance , trabecular bone , nuclear medicine , medicine , chemistry , osteoporosis , biology , radiology , pathology , surgery , physics , microbiology and biotechnology

Measurements have been made in the rat femur in vivo and ex vivo by using an asymmetric spin echo technique of T 2′ , the susceptibility contribution to T 2 *. The trabecular spacing in this study in rat bone is considerably less than in previous studies in the human. A significant increase in T 2′ was seen in vivo 3 mm proximal to the growth plate with ovariectomy (a model of osteopenia), from 8.1 ± 0.7 to 10.0 ± 0.6 ms. Parallel changes in trabecular bone mineral density measured by quantitative computed tomography were found. T 2′ was higher in living bones than in the same bones measured post mortem .

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