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Determinants of tissue delivery for 129 Xe magnetic resonance in humans
Author(s) -
Peled Sharon,
Jolesz Ferenc A.,
Tseng ChingHua,
Nascimben Luigino,
Albert Mitchell S.,
Walsworth Ronald L.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360303
Subject(s) - xenon , isotopes of xenon , nuclear magnetic resonance , magnetic resonance imaging , relaxation (psychology) , magnetization , chemistry , physics , atomic physics , magnetic field , medicine , quantum mechanics , radiology , psychology , social psychology
Magnetic resonance imaging using laser‐polarized 129 Xe is a new technique first demonstrated by Albert et al. (Nature 370, 1994) who obtained a 129 Xe image of an excised mouse lung. This paper describes the factors influencing the accumulation of inhaled, polarized 129 Xe in human tissue. The resulting model predicts the 129 Xe magnetization in different tissues as a function of the time from the start of inhalation, the tissue perfusion rate and partition coefficient for xenon, and the relevant T 1 decay times. The relaxation times of 129 Xe in biological tissues are not yet known precisely. Substitution of estimated values for these parameters results in an expected signal‐to‐noise ratio (SNR) from polarized 129 Xe MR in the brain of approximately 2% of the equivalent SNR from proton MR.