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Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia
Author(s) -
van der Toorn Annette,
Syková Eva,
Dijkhuizen Rick M.,
Vořišek Ivan,
Vargová Lydia,
Škobisová Evan,
van Lookeren Campagne Menno,
Reese Torsten,
Nicolay Klaas
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360110
Subject(s) - tortuosity , ischemia , effective diffusion coefficient , extracellular , tetramethylammonium , chemistry , intracellular , medicine , magnetic resonance imaging , biochemistry , radiology , ion , organic chemistry , porosity
To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1 H MRS/MRI and 31 P MRS, respectively. The time courses of the MR parameters were compared with changes in the extracellular space (ECS) volume fraction (α) and tortuosity (λ), determined from concentration‐time profiles of tetramethylammonium applied by iontophoresis. The data show a decrease of the ADC of tissue water after induction of global ischemia of which the time course strongly correlates with the time course of the decrease in the ECS volume fraction and the increase in ECS tortuosity. This indicates that cell swelling is an important cause for the ADC decrease of water.