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Spectroscopic imaging of human brain glutamate by water‐suppressed J ‐refocused coherence transfer at 4.1 T
Author(s) -
Pan Jullie W.,
Mason Graeme F.,
Pohost Gerald M.,
Hetherington Hoby P.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360103
Subject(s) - coherence (philosophical gambling strategy) , glutamate receptor , white matter , nuclear magnetic resonance , imaging phantom , human brain , spin echo , sequence (biology) , physics , fast spin echo , magnetization transfer , chemistry , magnetic resonance imaging , neuroscience , optics , biology , medicine , biochemistry , receptor , quantum mechanics , radiology
The authors report the development and implementation of a water‐suppressed J ‐refocused coherence transfer sequence to observe glutamate in human brain at 4.1 T. The sequence is modeled for I 2 S 2 and I 2 S 2 M spin systems analytically and plotted for a range of echo times. In this sequence, water suppression and refocusing of J ‐coupled resonances are achieved through a brief multiple quantum step without significant loss of signal. Phantom data are shown. Human brain spectroscopic imaging of glutamate, acquired with a total echo of 36 ms, demonstrates the application of the sequence to observe gray and white matter differences in glutamate content.