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Observation of resolved glucose signals in 1 H NMR spectra of the human brain at 4 Tesla
Author(s) -
Gruetter Rolf,
Garwood Michael,
Uǧurbil Kǎmil,
Seaquist Elizabeth R.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360102
Subject(s) - nuclear magnetic resonance , chemistry , metabolite , spectral line , human brain , resolution (logic) , signal (programming language) , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , physics , chromatography , medicine , biochemistry , artificial intelligence , computer science , astronomy , psychiatry , programming language
Measurement of the resonances of glucose between 3.2 and 3.9 ppm in 1 H NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites. The H1 resonance of α‐D‐glucose at 5.23 ppm is resolved from other metabolite peaks, but potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits to suppress the water signal sufficiently to reliably detect glucose directly at 5.23 ppm by 1 H MRS and the estimated peak intensity is consistent with previous 13 C NMR quantification.