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Design of conformationally rigid dimeric MRI agents
Author(s) -
Shukla Rajesh,
Fernandez Maria,
Pilial Radhakrishna K.,
Ranganathan Ramachandran,
Ratsep Peter C.,
Zhang Xun,
Tweedle Michael F.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910350623
Subject(s) - linkage (software) , flexibility (engineering) , paramagnetism , chelation , chemistry , nuclear magnetic resonance , crystallography , stereochemistry , physics , biochemistry , organic chemistry , condensed matter physics , gene , statistics , mathematics
The conformational flexibility of the linkage mechanism or tether between paramagnetic metal centers is explored to assess optimal structural characteristics of multirneric MRI contrast agents. Two dimeric paramagnetic chelates differing in linkage flexibility but similar in symmetry are compared. Relaxivity, water hydration number, and reorientation times of the chelate groups are obtained, and the results demonstrate that greater linkage flexibility reduces overall relaxiv′rty.