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A Modified sub‐second fast‐STEAM sequence incorporating bipolar gradients for in vivo diffusion imaging
Author(s) -
Yongbi Martin N.,
Ding Shujun,
Dunn Jeffrey F.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910350620
Subject(s) - diffusion , nuclear magnetic resonance , in vivo , diffusion mri , chemistry , materials science , sequence (biology) , diffusion imaging , analytical chemistry (journal) , nuclear medicine , physics , magnetic resonance imaging , chromatography , biology , thermodynamics , medicine , microbiology and biotechnology , radiology , biochemistry
A modified high‐speed stimulated‐echo acquisition mode (STEAM) diffusion sequence (90°‐ TE /2−90°‐ TM ‐[α‐ TE /2‐STE] n ) incorporating bipolar diffusion gradients that are less sensitive to macroscopic motion‐induced artifacts is presented. Diffusion encoding was performed only during the first echo interval ( TE 1) with bipolar gradients that were implemented on all three mutually orthogonal axes. Calibration measurements on phantoms filled with water, isopropanol, and dimethyl sulfoxide yielded apparent diffusion coefficients (ADC) consistent with published values. Non‐ECG‐triggered in vivo images acquired on rat brain with relatively high b values (˜450 s/mm 2 ) indicated minimal motion artifacts. Evaluated ADCs averaged over the cortex, left mid‐brain, right mid‐brain, regions yielded (0.91 ± 0.02), (1.06 ± 0.02), (1.01 ± 0.03) × 10 −3 mm 2 s −1 , respectively.