Regional myocardial oxygen tension:  19 F MRI of sequestered perfluorocarbon | Zendy

Shukla Himu P. | Zendy; Mason Ralph P. | Zendy; Bansal Navin | Zendy; Antich Peter P. | Zendy

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Regional myocardial oxygen tension: 19 F MRI of sequestered perfluorocarbon

Author(s) -

Shukla Himu P.,

Mason Ralph P.,

Bansal Navin,

Antich Peter P.

Publication year - 1996

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910350607

Subject(s) - oxygen tension , oxygen , chemistry , nuclear magnetic resonance , relaxometry , relaxation (psychology) , magnetic resonance imaging , medicine , radiology , physics , spin echo , organic chemistry

A novel noninvasive method of measuring local myocardial oxygen tension (pO 2 ) In the perfused rat heart using 19 F MRI is demonstrated. Tissue pO 2 was determined on the basis of the 19 F spin‐lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19 F MRI now provides 3D spatial resolution indicating local cardiac pO 2 under normally perfused, globally ischemic, and regionally ischemic conditions.

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