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Single‐shot diffusion MRI of human brain on a conventional clinical instrument
Author(s) -
Liu Guoying,
Van Gelderen Peter,
Duyn Jeff,
Moonen Chrit T. W.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910350508
Subject(s) - nuclear magnetic resonance , pulse sequence , scanner , flip angle , spin echo , single shot , diffusion , diffusion mri , homogeneity (statistics) , chemistry , physics , biomedical engineering , magnetic resonance imaging , optics , computer science , medicine , radiology , thermodynamics , machine learning
A single‐shot diffusion MRI technique on a standard clinical 1.5T scanner is presented. The method incorporates the following elements: (a) an inversion RF pulse followed by a delay of 1.3 s to null cerebral spinal fluid (CSF) signal, (b) a stimulated echo sequence ( TE =56 ms, TM=100 ms) to obtain strong diffusion weighting, (c) a single‐shot gradient‐ and spin‐echo (GRASE) sequence for imaging with a modified k ‐space trajectory and Carr‐Purcell Meiboom‐Gill (CPMG)‐phase cycle. The trace of the diffusion coefficient obtained with this approach is in good agreement with values reported for animal brain, and for recent human studies. It is demonstrated that single‐shot diffusion imaging of human brain is feasible on an unmodified standard instrument without high‐gradient slew rate or extreme field homogeneity.