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Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain
Author(s) -
Charles H. Cecil,
Lazeyras François,
Tupler Larry A.,
Krishnan K. Ranga R.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910350422
Subject(s) - reproducibility , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , creatine , context (archaeology) , magnetic resonance imaging , proton magnetic resonance , nuclear medicine , chemistry , medicine , radiology , chromatography , biology , physics , biochemistry , paleontology
The application of proton ( 1 H) magnetic resonance spectroscopic imaging (MRSI) allows for noninvasive, localized analyses of brain biochemistry; however, minimal work has been devoted to the evaluation of 1 H MRSI reproducibility. This study examined the reproducibility of 1 H MRSI from five normal subjects on two occasions, separated by 10 days. Reproducibility of the MR signal was evaluated in the context of automated shimming, automated processing, and accurate subject repositioning. Reliability measures for physicochemical indices (choline moieties, creatine, N ‐acetylaspartate, and myo ‐inositol) were moderately concordant across repeat studies. Gain variation and repositioning results were excellent. It has been concluded that 1 H MRSI reproducibility is adequate for serial studies of brain metabolism.