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Reperfused ischemia of the rat intestine: Detection by MR imaging with polylysine‐Gd‐DTPA enhancement
Author(s) -
Mottet Isabelle,
van Beers Bernard E.,
Delos Monique,
Goudemant JeanFrançois,
Jamart Jacques,
Demeure Roger,
Pringot Jacques
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910350117
Subject(s) - polylysine , small intestine , ischemia , medicine , nuclear medicine , t2 weighted , chemistry , magnetic resonance imaging , radiology , biochemistry
Abstract To detect reperfused ischemia of the rat intestine, T 2 ‐weighted spin‐echo images were acquired, followed by T 1 ‐weighted images before and after administration of polylysine‐Gd‐DTPA or Gd‐DTPA. Before administration of the contrast agent, the reperfused intestine was hyperintense on T 2 ‐weighted images, and to a lesser extent on T 1 ‐weighted images. After administration of polylysine‐Gd‐DTPA, the reperfused intestine enhanced more than the normal one, giving a significantly better contrast‐to‐noise (CNR) ratio than on unenhanced images. Gd‐DTPA induced the same enhancement of the reperfused and the normal intestine and the CNR was lower than on unenhanced T 2 ‐weighted images. Reperfused intestinal ischemia could thus be better detected on polylysine‐Gd‐DTPA‐enhanced MR images than on unenhanced images or on Gd‐DTPA‐ enhanced images.