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Quantification of liver blood volume: comparison of ultra short ti inversion recovery echo planar imaging (ulstir‐epi), with dynamic 3d‐gradient recalled echo imaging
Author(s) -
Schwickert Heidi C.,
Roberts Timothy P. L.,
Shames David M.,
Dijke Cornelis F. Van,
Disston Alexander,
Mühler Andreas,
Mann Jeffry S.,
Brasch Robert C.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340609
Subject(s) - gradient echo , nuclear magnetic resonance , magnetic resonance imaging , echo planar imaging , gadolinium , nuclear medicine , chemistry , medicine , radiology , physics , organic chemistry
An ultra‐short TI inversion recovery echo‐planar imaging (ULSTIR‐EPI) sequence was designed to reduce the influence of water exchange on fractional tissue blood volume (BV) estimation by measurement of T 1 ‐changes induced by a gadolinium‐based macromolecular contrast medium (MMCM). Fractional liver BV in rats, estimated by ULSTIR‐EPI was compared for accuracy to a fast T 1 ‐weighted three‐dimensional gradient‐echo (3D‐SPGR, 3D‐spoiled gradient recalled acquisition in a steady state) sequence using an in vitro inductively coupled plasma atomic emission spectroscopy (ICP‐AES) assay for BV as a standard. Liver images for fractional BV estimation were acquired in eight rats using both ULSTIR‐EPI and 3D‐SPGR before and after (within 3 to 12 min) intravenous bolus administration of albumin‐Gd‐DTPA 30 (0.05 mmol Gd/kg). Whereas both MR techniques may be useful for fractional tissue BV estimation, ULSTIR‐EPI offers certain advantages including greater accuracy, direct T 1 maps, and minimization of transendothelial proton exchange effects. 3D‐SPGR imaging offers better spatial resolution, current availability on standard clinical MR systems, and acceptable accuracy.