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In vivo measurement of partial oxygen pressure in large vessels and in the reticuloendothelial system using fast 19F‐MRI
Author(s) -
Nöth Ulrike,
Morrissey Sean P.,
Deichmann Ralf,
Adolf Holger,
Schwarzbauer Christian,
Lutz Joachim,
Haase Axel
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340513
Subject(s) - mononuclear phagocyte system , in vivo , partial pressure , oxygen pressure , nuclear magnetic resonance , chemistry , biomedical engineering , oxygen , medicine , pathology , physics , biology , microbiology and biotechnology , organic chemistry
Quantitative in vivo 19F‐MRI was performed in a rat model to monitor partial oxygen pressure (pO 2 ) using a perfluorocarbon (PFC) emulsion as contrast agent. On Days 1, 4, and 8 postin‐jection of the PFC emulsion, transaxial T 1 and pO 2 maps were acquired of the abdomen of rats that were consecutively ventilated with pure oxygen, air, and a mixture of 10% oxygen and 90% nitrogen. The images had a resolution of 0.75 mm x 0.75 mm x 2 mm and a total acquisition time of 24 min. In these images it was possible to distinguish between different vessels and hepatic and splenic tissue in the selected imaging plane. Serial 19F‐MRI measurements on the different days postinjection of the PFC allowed to determine separately the pO 2 of arterial and venous blood and the intracellular pO 2 in macrophages of the liver and spleen.