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Validation of 19 f‐magnetic resonance determination of myocardial blood volume
Author(s) -
Rottman Gerald A.,
Judd Robert M.,
Yin Frank C. P.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340421
Subject(s) - emulsion , nuclear magnetic resonance , magnetic resonance imaging , volume (thermodynamics) , biodistribution , chemistry , albumin , blood volume , biomedical engineering , medicine , cardiology , radiology , in vitro , biochemistry , physics , quantum mechanics
The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of 19 F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and 125 I‐albumin. Measurement of myocardial vascular volume by 19 F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.