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In vivo 31 p spectroscopy study of treated and untreated recovery of rat partial brain ischemia
Author(s) -
Macri Maria Antonietta,
Campanella Renzo,
Luca Francesco De,
Montalbano Antonio,
Taggi Franco,
Maraviglia Bruno
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340410
Subject(s) - ischemia , in vivo , forebrain , hypoxia (environmental) , animal model , occlusion , chemistry , medicine , anesthesia , oxygen , biology , central nervous system , organic chemistry , microbiology and biotechnology
Quantitative 31 P NMR was used to follow the time variation of the hypometabolic response to hypoxic partial ischemia in an animal model. The purpose of the study was to establish the value of this repeated spectroscopy operating by means of a surface coil. It aimed at determining whether a therapeutic intervention could influence the transient changes occurring during the insult or early recovery. A pharmacological substance was thus used during a reversible forebrain ischemia, induced by a combination of vascular occlusion and mild hypoxia in two groups of rats. As an available and convenient example, L‐carnitine was chosen. Statistical analysis of the experimental results revealed a significant difference of the P 1 and PCr levels between treated and untreated animals.