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Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Author(s) -
Biswal Bharat,
Zerrin Yetkin F.,
Haughton Victor M.,
Hyde James S.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340409
Subject(s) - human brain , resting state fmri , neuroscience , correlation , cortex (anatomy) , nuclear magnetic resonance , motor cortex , echo (communications protocol) , blood oxygenation , intensity (physics) , echo planar imaging , functional magnetic resonance imaging , physics , magnetic resonance imaging , psychology , medicine , computer science , mathematics , computer network , geometry , stimulation , radiology , quantum mechanics
An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation ( P < 10 −3 ) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.