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The apparent diffusion constant measured by mri correlates with po 2 in a rif‐1 tumor
Author(s) -
Dunn Jeff F.,
Ding Shujun,
O'Hara Julia A.,
Liu Ke J.,
Rhodes Erik,
Weaver John B.,
Swartz Harold M.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340405
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , oxygen tension , fibrosarcoma , nuclear medicine , diffusion weighted magnetic resonance imaging , electron paramagnetic resonance , oxygen , chemistry , effective diffusion coefficient , medicine , pathology , radiology , physics , organic chemistry
As tissue oxygen tension (pO 2 is an important variable in cancer therapy, it would be of major clinical benefit to be able to measure pO 2 noninvasively. Current methods for determining pO 2 in clinical settings are limited to superficial tumors. The authors measured the apparent diffusion constant (ADC) in an implanted murine fibrosarcoma (RIF‐1) using magnetic resonance imaging and correlated the ADC with tissue pO 2 measured by electron paramagnetic resonance oximetry. The ADC correlates significantly with tissue pO 2 in this tumor ( r = 0.89; n = 14) and so may provide a noninvasive index of pO 2 in tumors.