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1 H mrs of human brain abscesses in vivo and in vitro
Author(s) -
Rémy Chantal,
Grand Sylvie,
Laï Ernest Sam,
Belle ValéRie,
Hoffmann Dominique,
Berger FrançOis,
Estève FrançOis,
Ziegler Anne,
Bas JeanFrsançOis Le,
Benabid Alim L.,
Décorps Michel,
Segebarth Christoph M.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340404
Subject(s) - in vivo , in vitro , brain abscess , abscess , nuclear magnetic resonance , magnetic resonance imaging , chemistry , alanine , pathology , medicine , nuclear medicine , biology , amino acid , biochemistry , radiology , surgery , physics , microbiology and biotechnology
Five patients, each with a brain abscess, were examined by means of 1 H MR spectroscopic imaging in vivo. The aspirated pus was analyzed in vitro by means of 1D and 2D COSY 1 H MRS. In addition to resonance lines from compounds (lactate, alanine and lipids) often found in the spectra from intracranial tumors, resonance lines were detected from a number of markers of infectious involvement (acetate, succinate, and various amino acids). These results suggest that 1 H MRS in vivo might contribute in establishing noninvasively a differential diagnosis between brain abscess and tumor.