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NMR relaxation rates and blood oxygenation level
Author(s) -
Meyer M.E,
Yu Olivier,
Eclancher Bernard,
Grucker Daniel,
Chambron Jacques
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340215
Subject(s) - relaxation (psychology) , chemistry , proton , nuclear magnetic resonance , diffusion , paramagnetism , hemoglobin , analytical chemistry (journal) , thermodynamics , physics , nuclear physics , chromatography , psychology , social psychology , biochemistry , quantum mechanics
A linear relationship between the proton relaxation rates and the fraction of deoxyhemoglobin of circulating whole blood ( f Hb ) has been established in vitro at 4.7 T. These results have been interpreted on the basis of the additivity of relaxation rates. The slope of the lines of transverse relaxation rates ( R 2 ) versus f Hb was found to increase with interpulse delay in Carr‐Purcell Meiboom‐Gill (CPMG) experiments. The Luz‐Mei‐boom relation applied to this interpulse delay dependence of R 2 suggests a two‐site chemical exchange rather than a diffusion mechanism. The 1‐ms water proton exchange time derived from these observations has been interpreted in terms of exchange between exchangeable protons close to the paramagnetic center of hemoglobin and protons of bulk water.