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Quantitative analysis of regional left ventricular function after myocardial infarction in the pig assessed with cine magnetic resonance imaging
Author(s) -
Holman Eduard R.,
Vliegen Hubert W.,
Van Geest Rob J. Der,
H. C. Reiber Johan,
Van Dijkman Paul R. M.,
Laarse Arnoud Van Der,
Roos Albert De,
Van Wall Ernst E. Der
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340206
Subject(s) - ventricle , magnetic resonance imaging , multislice , myocardial infarction , medicine , nuclear medicine , infarction , thickening , gadolinium , radiology , cardiology , chemistry , organic chemistry , polymer science
To assess the accuracy of quantitative analysis of global and regional wall motion and wall thickening of the left ventricle with cine magnetic resonance (MR), images obtained in eight pigs before and after myocardial infarction were compared with those obtained using gadolinium diethylenetriaminepen‐taacetic acid (Gd‐DTPA)‐enhanced multislice spin‐echo MR imaging and determination of pathology. The region with abnormal wall motion and wall thickening, as determined with cine MR imaging, identified the same region of infarction as indicated by Gd‐DTPA‐enhanced spin‐echo MR imaging and pathology. Within the infarcted region wall motion and wall thickening analyzed with the centerline method were significantly reduced. We conclude that the use of quantitative analysis of cine MR images accurately determines localization and extent of regional left ventricular dysfunction in the infarcted heart in vivo . This analysis using dedicated software including the centerline method allows sequential assessment of regional left ventricular function in normal and infarcted hearts.