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Bsh distributions in the canine head and a human patient using 11 b mri
Author(s) -
Bradshaw Kenneth M.,
Schweizer Martin P.,
Glover Gary H.,
Rock Hadley J.,
Tippets Richard,
Tang PengPeng,
Davis Wayne L.,
Peter Heilbrun M.,
Johnson Suzanne,
Ghanem Tamer
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910340109
Subject(s) - nuclear medicine , gliosarcoma , brain tissue , in vivo , chemistry , boron , glioblastoma , biomedical engineering , medicine , organic chemistry , cancer research , microbiology and biotechnology , biology
A 3D projection reconstruction (3DPR) method was used to obtain in vivo 11 B images in a large canine brain tumor model and in a human infused with borocaptate sodium (BSH). Studies were performed in dogs with and without gliosarcomas implanted and grown to a size of 2–3 cm. The 3DPR method demonstrates a signal‐to‐noise ratio (SNR) that allows qualitative kinetic studies of the boron compound in normal and tumor tissue of the head. The measurements indicate initial uptake of the BSH compound in tumor to be less than that in muscle with no uptake in normal brain tissue. Moreover, uptake of BSH in tissue was found to lag the boron concentration in blood with delays that depend on tissue type. In addition, the first human boron images were obtained on a patient who underwent surgical resection and volumetric debulking of a large (7 cm) glioblastoma multiforme. BSH was readily taken up in residual tumor tissue, while diffusion into the resection volume was slower.