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The Estimation of Local Brain Temperature by in Vivo 1 H Magnetic Resonance Spectroscopy
Author(s) -
Cady Ernest B.,
D'Souza Patricia C.,
Penrice Juliet,
Lorek Ann
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330620
Subject(s) - nuclear magnetic resonance , spectroscopy , nuclear magnetic resonance spectroscopy , in vivo , chemistry , magnetic resonance imaging , analytical chemistry (journal) , medicine , biology , physics , chromatography , radiology , quantum mechanics , microbiology and biotechnology
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1 H magnetic resonance spectroscopy are described: a partially water‐suppressed binomial sequence and non‐water‐suppressed point‐resolved spectroscopy. Relative to N ‐acetylaspartate (Naa), water chemical shift (θ H2O‐Naa ) in piglet brain depended linearly on temperature from 30° to 40°C: temperature was 286.9–94.0 θ H2O‐Naa ° C. Thalamic temperature in six normal infants was 38.1° ± 0.4° C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.