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Deuterium Magnetic Resonance Imaging of Rabbit Eye in Vivo
Author(s) -
Obata Takayuki,
Ikehira Hiroo,
Koga Masahisa,
Yoshida Katsuya,
Kimura Fukuko,
Tateno Yukio
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330417
Subject(s) - nuclear magnetic resonance , magnetic resonance imaging , deuterium , chemistry , pulse sequence , in vivo , nuclear medicine , materials science , medicine , physics , radiology , microbiology and biotechnology , quantum mechanics , biology
We used deuterium magnetic resonance imaging ( 2 H MRI) to visualize water movement in the rabbit eye. Dynamic 2 H MRI was obtained every 3.5 min at 2 tesla by FLASH pulse sequence ( TR , 300 ms; TE , 10 ms; α = 90°) with a slice thickness of 10 mm using a surface coil (4 cm in diameter). After topical administration (0.2 ml D 2 O), only the aqueous chamber was imaged, and the signals decreased mono‐exponentially. The flow rate was 0.113/min, in agreement with that already reported. After intravenous administration of deuterated saline (3 ml/kg), the aqueous chamber became visible first during imaging, then by the vitreous body. The signals around the lens were only faintly detected. Thus, deuterium MRI was determined to be useful for visualizing water movement in the eye.