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EPI Imaging of Global Increase of Brain MR Signal with Breath‐hold Preceded by Breathing O 2
Author(s) -
Kwong Kenneth K.,
Wanke Isabel,
Donahue Kathleen M.,
Davis Timothy L.,
Rosen Bruce R.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330322
Subject(s) - breathing , apnea , hemodynamics , medicine , nuclear magnetic resonance , respiratory system , human brain , magnetic resonance imaging , nuclear medicine , cardiology , neuroscience , anesthesia , psychology , physics , radiology
Brain MR signal has been observed to decrease during cessation of breathing due to the increase of deoxyhemoglobin in the blood. However, for both animal and human studies, we have demonstrated that if the subjects breathed 100% oxygen in advance of apnea for a short time, T 2 *‐weighted MR brain signal increased when breathing was stopped for a period of 30–60 s. This demonstrates the possibility of measuring responses to hemodynamic change throughout the entire brain with a single respiratory perturbation in a rapid, reliable, and robust manner.