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3D 31 P Spectroscopic Imaging of the Human Heart at 4.1 T
Author(s) -
Hetherington Hoby P.,
Luney Derek J. E.,
Thomas Vaughan J.,
Pan Jullie W.,
Ponder Steven L.,
Tschendel Otmar,
Twieg Donald B.,
Pohost Gerald M.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330318
Subject(s) - nuclear magnetic resonance , chemistry , nuclear medicine , physics , medicine
High field (4 Tesla) spectroscopic imaging offers the advantages of increased signal‐to‐noise ratio and the possibility of acquiring high resolution metabolite images. We have applied a three dimensional spectroscopic imaging sequence using a sparse Gaussian sampling method to acquire phosphocreatine (PCr) images of the human heart with 8‐cc voxels. PCr images enabled observation of the septum, left ventricular free wall, apex, and skeletal muscle. Quantitative evaluation of the 50 myocardial voxels acquired from 10 studies of healthy adults revealed a PCr/adenosine triphosphate (ATP) ratio of 1.80 ± 0.32 after correction for saturation effects. Due to the small size of the voxels and the ability to choose the location of the volumes to minimize inclusion of blood, no correction for blood pool ATP was required. The calculated PCr/ATP ratio is in agreement with other studies at 1.5 and 4.0 T.