Premium
Changes in T 2 *‐Weighted Images During Hyperoxia Differentiate Tumors from Normal Tissue
Author(s) -
Kuperman Vadim Y U.,
River Jonathan N.,
Lewis Martha Z.,
Lubich Leslie M.,
Karczmar Gregory S.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330306
Subject(s) - hyperoxia , intensity (physics) , nuclear medicine , chemistry , relaxation (psychology) , pathology , anatomy , nuclear magnetic resonance , oxygen , medicine , physics , organic chemistry , quantum mechanics
Experiments were performed to determine whether changes in T 2 *‐weighted MR images during and after hyperoxia differentiate tumors from normal tissue. Mammary adenocarcinomas implanted in the right hind limbs of rats were studied. Gradient echo images were obtained at 2 Tesla with an evolution time of 20 ms and a recycle time of 1 s. Breathing gas was either air or 100% O 2 . Significant increases in image intensity were observed in tumor centers and rims during hyperoxia while much smaller changes were detected in the surrounding muscle. The relaxation rate (1/ T 2 *) in tumors decreased during hyperoxia by an average of 2.5 ± 1.0 s −1 , while in muscle the average change was an increase of 0.6 ± 2.1 s −1 . The largest decreases in relaxation rate were detected in non‐necrotic tumor regions with relatively low density of blood vessels. Immediately following hyperoxia significant decreases in intensity were detected in tumors while much smaller decreases were detected in the surrounding muscle.