Premium
MR Imaging with Hyperpolarized 3 He Gas
Author(s) -
Middleton Hunter,
Black Robert D.,
Saam Brian,
Cates Gordon D.,
Cofer Gary P.,
Guenther Robert,
Happer William,
Hedlund Lawrence W.,
Alan Johnson G.,
Juvan Kim,
Swartz John
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330219
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , pulse sequence , hyperpolarization (physics) , signal (programming language) , helium , polarization (electrochemistry) , pulse (music) , physics , chemistry , materials science , optics , nuclear magnetic resonance spectroscopy , atomic physics , computer science , medicine , radiology , detector , programming language
Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacular signal from this normally signal‐deficient organ system offers great promise for eventual in vivo imaging experiments. Fast 2D and 3D GRASS sequences with very small flip angles were employed to conserve the nonrenewable longitudinal magnetization. We discuss various unique features associated with performing MRI with hyperpolarized gases, such as the selection of the noble gas species, polarization technique, and constraints on the MR pulse sequence.