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Barbiturate‐Reversible Reduction of Water Diffusion Coefficient in Flurothyl‐Induced Status Epilepticus in Rats
Author(s) -
Zhong Jianhui,
Petroff Ogen A. C.,
Prichard James W.,
Gore John C.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330216
Subject(s) - status epilepticus , barbiturate , anesthesia , diffusion , reduction (mathematics) , chemistry , effective diffusion coefficient , nuclear magnetic resonance , medicine , epilepsy , mathematics , thermodynamics , magnetic resonance imaging , physics , psychiatry , radiology , geometry
Rat brains (n = 17) with flurothyl‐induced status epilepticus (SE) have been imaged with a gradient‐echo diffusion‐weighted imaging sequence at 2.0 T. The apparent water diffusion coefficient (ADC) decreased during seizure discharges. The magnitude of the ADC reduction correlated well with the duration of flurothyl exposure. A 17% reduction in the water ADC compared with preseizure condition was observed in rats with the longest flurothyl exposure time. In 13 rats, pentobarbital was used to arrest the electrographic seizure activity. ADC values began to return to normal a few minutes after the injection. In four rats with no pentobarbital administration, ADC values remained depressed up to 1 h after seizure onset. The results suggest that diffusion‐weighted MR imaging may be useful for mapping recent intense seizure activity in human patients with medically intractable epilepsy.