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Effects of Myocardial Water Exchange on T 1 Enhancement during Bolus Administration of MR Contrast Agents
Author(s) -
Judd Robert M.,
Atalay Michael K.,
Rottman Gerald A.,
Zerhouni Elias A.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330211
Subject(s) - bolus (digestion) , gadolinium , perfusion , chemistry , magnetic resonance imaging , extracellular , nuclear medicine , medicine , cardiology , radiology , biochemistry , organic chemistry
Interpretation of first‐pass myocardial perfusion studies employing bolus administration of T 1 magnetic resonance (MR) contrast agents requires an understanding of the relationship between contrast concentration and image pixel intensity. The potential effects of myocardial water exchange rates among the intravascular, interstitial, and cellular compartments on this relationship are controversial. We directly studied these issues in isolated, nonbeating canine interventricular septa. Myocardial T 1 was measured three times/s during bolus transit of intravascular (albumin‐Gd‐DTPA and poly‐lysine‐Gd‐DTPA) and extracellular (gadoteridol) contrast agents. For polylsine‐Gd‐DTPA, the peak changes in myocardial 1/ T 1 (ΔR1) scaled nonlinearly with perfusate contrast concentration whereas a linear relationship would be expected for fast water exchange among the vascular, interstitial, and cellular compartments. For all agents, the peak ΔR1 were much smaller than the values expected on the basis of fast myocardial water exchange. The data demonstrate that in isolated myocardial tissue, myocardial T 1 enhancement during bolus administration of contrast can be strongly affected by myocardial water exchange for both intravascular and extracellular MR contrast agents.