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Water‐Macromolecular Proton Magnetization Transfer in Infarcted Myocardium: A Method to Enhance Magnetic Resonance Image Contrast
Author(s) -
Scholz Thomas D.,
Hoyt Robert F.,
Deleonardis John R.,
Ceckler Toni L.,
Balaban Robert S.
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330206
Subject(s) - magnetic resonance imaging , magnetization transfer , ligation , myocardial infarction , infarction , relaxation (psychology) , nuclear magnetic resonance , in vivo , medicine , artery , contrast (vision) , chemistry , cardiology , radiology , biology , physics , microbiology and biotechnology , optics
Water proton nuclear magnetic resonance relaxation times and magnetization transfer (MT) parameters of rat hearts were studied 24 h or 4 weeks after ligation of the left coronary artery or sham operation. Compared with sham‐operated controls, measured relaxation times ( T 1sat' and T 2 ) of both acute and chronic myocardial infarction increased. The MT effect significantly decreased in the infarcted myocardium. The changes in relaxation times and MT effect were significantly greater in chronic infarcts compared with acute infarcts. Improvements in calculated image contrast between normal and infarcted tissue were supported by images of ex vivo hearts with chronic infarction. Image contrast was increased at short echo times in the presence of macromolecular proton pool irradiation. Exploiting changes in tissue MT following myocardial infarction to enhance contrast between normal and infarcted tissue should allow improved identification and characterization of infarcted myocardium.