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Noninvasive MRI Thermometry with the Proton Resonance Frequency (PRF) Method: In Vivo Results in Human Muscle
Author(s) -
Poorter John De,
Wagter Carlos De,
Deene Yves De,
Thomsen Carsten,
Ståhlberg Freddy,
Achten Eric
Publication year - 1995
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910330111
Subject(s) - in vivo , bolus (digestion) , nuclear magnetic resonance , materials science , biomedical engineering , magnetic resonance imaging , imaging phantom , nuclear medicine , radiology , medicine , physics , anatomy , microbiology and biotechnology , biology
The noninvasive thermometry method is based on the temperature dependence of the proton resonance frequency (PRF). High‐quality temperature images can be obtained from phase information of standard gradient‐echo sequences with an accuracy of 0.2°C in phantoms. This work was focused on the in vivo capabilities of this method. An experimental setup was designed that allows a qualitative in vivo verification. The lower‐leg muscles of a volunteer were cooled and afterwards reheated with an external water bolus. The temperature of the bolus water varied between 17°C and 37°C. The in vivo temperature images can be used to extract the temperature in muscle tissue. The data in the fat tissue are difficult to interpret because of the predominance of susceptibility effects. The results confirm the method's potential for hyperthermia control.