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q ‐Space imaging of the brain
Author(s) -
King Martin D.,
Houseman John,
Roussel Simon A.,
Van Bruggen Nicholas,
Williams Stephen R.,
Gadian David G.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320605
Subject(s) - nuclear magnetic resonance , computer science , space (punctuation) , artificial intelligence , neuroscience , physics , psychology , operating system
q ‐Space imaging (Callaghan, J. Magn. Reson. 88,493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherent‐displacement probability density distribution. Two groups of mice were studied, a normal group and one in which surgery had been performed to reduce the supply of blood to the forebrain. In the normal group the incoherent displacement of water was reducedpostmortem. Four of the surgically treated mice yielded displacement profiles that resembled those obtained postmortem; the remaining two were near normal. This study demonstrates the feasibility of in vivo q‐space imaging. The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusion‐weighted imaging.