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Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice
Author(s) -
Preece Nicholas E.,
Amor Sandra,
Baker David,
Gadian David G.,
O'Neill Janet K.,
Urenjak Jutta
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320603
Subject(s) - encephalomyelitis , spinal cord , taurine , creatine , semliki forest virus , chemistry , medicine , endocrinology , central nervous system , biology , biochemistry , neuroscience , rna , amino acid , gene
In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N ‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo ‐inositol during acute and again during chronic relapsing EAE. The ratio of N ‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.