Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice | Zendy

Preece Nicholas E. | Zendy; Amor Sandra | Zendy; Baker David | Zendy; Gadian David G. | Zendy; O'Neill Janet K. | Zendy; Urenjak Jutta | Zendy

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Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice

Author(s) -

Preece Nicholas E.,

Amor Sandra,

Baker David,

Gadian David G.,

O'Neill Janet K.,

Urenjak Jutta

Publication year - 1994

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910320603

Subject(s) - encephalomyelitis , spinal cord , taurine , creatine , semliki forest virus , chemistry , medicine , endocrinology , central nervous system , biology , biochemistry , neuroscience , rna , amino acid , gene

In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N ‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo ‐inositol during acute and again during chronic relapsing EAE. The ratio of N ‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.

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