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Localized MR 1H spectroscopy reveals alterations of susceptibility in bone marrow with hemosiderosis
Author(s) -
Schick Fritz,
Einsele Hermann,
Kost Renate,
Duda Stephan H.,
Horny HansPeter,
Lutz Otto,
Claussen Claus D.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320408
Subject(s) - hemosiderin , bone marrow , pathology , iliac crest , hemosiderosis , bone marrow transplantation , transplantation , haematopoiesis , chemistry , nuclear magnetic resonance , leukemia , medicine , nuclear medicine , anatomy , biology , stem cell , genetics , physics
A noninvasive investigation of the structure of hemopoietic bone marrow is based on the determination of the magnetic field distribution within small volume elements in vertebral bodies by localized 1 H MR spectroscopy. In patients with he‐matological diseases the status of the bone marrow was found to considerably influence the homogeneity of the magnetic field in trabecular bone in vivo. The line widths of the 1 H signals were evaluated in follow‐up studies during initial chemotherapy of eight patients with leukemia. lntraindividual comparison revealed significant broadening of the field distribution after a few weeks of cytotoxic treatment in five of the patients. Additionally, 19 patients after bone marrow transplantation showed significantly broader field distributions in the lipid signals than 13 matched healthy volunteers. These alterations of the microscopic field homogeneity were not caused by trabecular density effects. Iliac crest biopsies revealed high amounts of hemosiderin in the cases with broadened line widths. Ten of the 19 patients after bone marrow transplantation showed high amounts of hemosiderin and broad lines in the spectra. The content of hemosiderin of the other patients was not significantly increased.