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Observation of cardiac lipids in humans by localized 1 H magnetic resonance spectroscopic imaging
Author(s) -
den Hollander Jan A.,
Evanochko William T.,
Pohost Gerald M.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320205
Subject(s) - nuclear magnetic resonance , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , volume (thermodynamics) , in vivo , in vivo magnetic resonance spectroscopy , chemistry , creatine , medicine , radiology , physics , biology , biochemistry , microbiology and biotechnology , quantum mechanics
Different approaches are being explored for the noninvasive observation of myocardial lipids in the human heart by in vivo 1 H NMR spectroscopy. One approach is to measure cardiac lipids using a combination of volume selection and 2D gradient phase encoding. From these data sets lipid images can be reconstructed. By comparing these lipid images with 1 H MR scout images, it is demonstrated that these signals represent epicardial and pericardial lipid. By selecting a smaller bar‐shaped volume combined with 1D phase encoding or by using single volume techniques, it is possible to avoid most of the pericardial and epicardial lipid to obtain myocardial 1 H NMR spectra of the human heart showing lipid signals, as well as trimethylamine and (phospho)creatine signals. These measurements demonstrate the feasibility of obtaining 1 H NMR spectra of the human myocardium.