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In Vivo detection of a boron‐neutron‐capture agent in melanoma by proton observed 1 H ‐ 10 B double resonance
Author(s) -
Bendel Peter,
Zilberstein Judith,
Salomon Yoram
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320204
Subject(s) - in vivo , boron , proton , neutron capture , nuclear magnetic resonance , chemistry , spectroscopy , radiochemistry , nuclear magnetic resonance spectroscopy , neutron , analytical chemistry (journal) , chromatography , nuclear physics , physics , microbiology and biotechnology , organic chemistry , quantum mechanics , biology
The Cesium salt of BSSB (Cs 4 B 24 H 22 S 2 ), a common boron‐neutron‐capture‐therapy (BNCT) agent, was injected into M2R mouse melanoma xenografts, and detected in vivo by 1 H‐observed, 10 B‐edited NMR spectroscopy. The technique of spin‐echo difference spectroscopy, in which a proton spin‐echo is detected following the alternating presence and absence of a 10 B 180° pulse was used. This method provides much higher sensitivity than direct 10 B NMR detection, and should thus be suitable for in vivo detection in patients about to undergo BNCT treatment, where the infused agents are 95% isotopically enriched in 10 B.