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An evaluation of the sensitivity of the intravoxel incoherent motion (IVIM) method of blood flow measurement to changes in cerebral blood flow
Author(s) -
Neil Jeffrey J.,
Bosch Coleen S.,
Ackerman Joseph J. H.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910320109
Subject(s) - intravoxel incoherent motion , cerebral blood flow , blood flow , nuclear magnetic resonance , sensitivity (control systems) , nuclear medicine , medicine , physics , magnetic resonance imaging , effective diffusion coefficient , radiology , electronic engineering , engineering
To evaluate the sensitivity of the intravoxel incoherent motion (IVIM) technique to changes in cerebral blood flow, we made measurements of IVIM parameters in rat brain under conditions of altered arterial pCO 2 . The arterial pCO 2 , was varied over a range which would be expected to change cerebral blood flow from roughly 50 to 500 ml/(100 g·min). The IVIM measurements were made with suppression of extravascular water signal. The parameters f ′ (the apparent fraction of spins which have “fast” pseudodiffusion), D 1 *(the “fast‐pseudodiffusion” coefficient), and D 2 * (the “slow‐pseudodiffusion” coefficient) all showed statistically significant positive linear correlations with arterial pCO 2 . These results suggest that the IVIM method, when used with suppression of extravascular water signal, is sensitive to changes in blood flow.