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Proton NMR observation of glycogen in vivo
Author(s) -
Chen Wei,
Avison Malcolm J.,
Bloch Gilles,
Shulman Robert G.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910310518
Subject(s) - nuclear magnetic resonance , relaxation (psychology) , in vivo , proton , chemistry , dipole , nuclear magnetic resonance spectroscopy , nuclear overhauser effect , physics , biology , nuclear physics , microbiology and biotechnology , organic chemistry , neuroscience
Our previous solution studies of the proton relaxation properties of glycogen H1 have shown significant dipolar cross–relaxation with intra‐ring H2 and inter‐ring H4′ protons characterized by a correlation time τ c = 2.7 × 10 −9 s. This leads to a significant negative Nuclear Overhauser Enhancement (NOE) of glycogen H1 following either transient or steady state perturbations of the longitudinal magnetization of dipolar coupled protons, especially H2 and H4′. Here we use the NOE to edit selectively the H1 resonance of glycogen in the rat liver in vivo using a surface coil probe. The approach shows the possibility of measuring glycogen in vivo with high sensitivity using 1 H NMR.