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India ink: A potential clinically applicable EPR oximetry probe
Author(s) -
Swartz Harold M.,
Liu Ke Jian,
Goda Fuminori,
Walczak Tadeusz
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910310218
Subject(s) - repeatability , inkwell , electron paramagnetic resonance , measure (data warehouse) , biomedical engineering , materials science , nuclear magnetic resonance , medicine , nanotechnology , chemistry , computer science , data mining , chromatography , composite material , physics
Using a material that already is in widespread use in humans, India ink, the first EPR measurements in a human have been made, using the India ink in a pre‐existing tattoo. The EPR spectra of India ink are very sensitive to the partial pressure of oxygen (PO 2 ), thereby making it feasible to use this approach to measure pO 2 in tissues in patients. This potentially provides a means to measure this parameter directly with a sensitivity, accuracy, and repeatability that have not been available previously, and thereby to be able to individualize and guide treatment of diseases such as cancer and peripheral vascular insufficiency.