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Effect of vitreous fluidity on the measurement of blood‐retinal barrier permeability using contrast‐enhanced MRI
Author(s) -
Berkowitz Bruce A.,
Wilson Charles A.,
Tofts Paul S.,
Peshock Ronald M.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910310110
Subject(s) - retinal , ophthalmology , contrast (vision) , retina , wilcoxon signed rank test , permeability (electromagnetism) , blood–retinal barrier , retinopathy , vitrectomy , medicine , nuclear magnetic resonance , chemistry , diabetic retinopathy , optics , visual acuity , mann–whitney u test , physics , biochemistry , endocrinology , membrane , diabetes mellitus
Abstract Breakdown of the blood‐retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast‐enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 ± 0.48 × 10 −4 cm/min, mean ± SEM, n = 5) to the contralateral gas‐compressed vitrectomized eyes (5.41 ± 0.54 × 10 −4 cm/min, n = 5). The effect of vitrectomy was not significant ( P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.