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Evaluation of radiation injury by 1 H and 31 P NMR of human urine
Author(s) -
Yushmanov Victor E.
Publication year - 1994
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910310107
Subject(s) - urine , chemistry , radiation , irradiation , metabolite , nuclear magnetic resonance , proton , phosphorus 31 nmr spectroscopy , spectral line , radiation injury , radiochemistry , nuclear medicine , nuclear magnetic resonance spectroscopy , physics , medicine , radiation therapy , nuclear physics , biochemistry , astronomy
1 H and 31 P NMR techniques were applied to study the changes in metabolite profiles in human urine resulting from radiation exposure following the Chemobyl reactor accident. In cases of acute leukemia and different accumulated doses of external radiation (from 0.20 to 4.00 Sv), the proton spectra were classified on the basis of the peaks due to N ‐trimethyl groups, creatinine, citrate, glycine, and hippurate. Unidentified resonances were observed between 15.9 and 21.4 ppm in six phosphorus spectra of patients with preleukemia and acute leukemia. Characteristic spectral changes were similar for external radiation and Incorporation‐induced internal irradiation. The spectral patterns described may serve as a criterion of radiation injury.